Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19코로나19 사망자의 SARS-CoV-2 뇌 부위 검출, 조직병리학, 유전자 발현 및 면역조절 변화Article Published on 2022-08-162022-09-11 Journal: Journal of neuropathology and experimental neurolo [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] Amygdala arising Autopsies Autopsy Blood Brain brains cerebellar cortex change Control COVID-19 COVID-19 cases cytokine Deafferentation detection Differentially expressed genes downregulation Encephalitis fraction Gene Expression Genes Hemorrhagic hemorrhagic encephalitis Histopathology immune immune response indicated involved marker microglia mucosa neuronal Non-COVID-19 olfactory olfactory bulb portal receptor reduced reduction Region Regional RNA polymerase RNA sequence RNA sequences RNA-dependent RNA polymerase RNAseq RT-PCR S gene SARS-CoV-2 SARS-CoV-2 E gene SARS-CoV-2. sequence serum Significant subject upregulation viral sequence virus with COVID-19 [DOI] 10.1093/jnen/nlac056 PMC 바로가기 [Article Type] Article
Analyzing single cell transcriptome data from severe COVID-19 patients중증 코로나19 환자의 단세포 전사체 데이터 분석Article Published on 2022-04-212022-09-11 Journal: STAR protocols [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] bioinformatics Cell cell type cell types cellular Complete COVID-19 COVID-19 severity database detect disease-associated enrichment analysis Gene Expression Genomics Health Sciences identify immunology in silico in vitro in vivo marker gene Molecular biology protocol Regulatory resources RNAseq RNAseq. severe COVID-19 severe COVID-19 patient Single Cell single-cell Transcriptome transcriptomics upregulated upregulation [DOI] 10.1016/j.xpro.2022.101379 PMC 바로가기 [Article Type] Article
Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory PathologyResearch Article Published on 2022-03-012023-06-15 Journal: mBio [Category] COVID19(2023년), MERS, SARS, [키워드] CFTR coronavirus lung inflammatory pathology micro RNAs NLRP3 RNAseq SARS-CoV Virus-host interaction [DOI] 10.1128/mbio.03135-21 PMC 바로가기 [Article Type] Research Article
Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19Research article Published on 2022-02-232022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] adaptive immune system circulating neutrophil cleavage cleaved clotting coagulation factor COVID-19 expressed expression Factor factor V form hospitalized patient identify immunofluorescence microscopy immunology in vitro Increased inhibitor leukocyte leukocytes liver Lung disease lymphopenia Microbiology Monocytes mononuclear cells mRNA Neutrophils omics Peripheral blood proliferation Proteomic analysis reduce RNAseq scRNAseq severe COVID-19 severe disease suppress T regulatory cell T-cell thrombin transcriptomics Whole blood with COVID-19 [DOI] 10.1016/j.isci.2022.103971 [Article Type] Research article
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2골수 세포 인터페론 반응은 SARS-CoV-2 제거와 관련이 있습니다Article Published on 2022-02-032022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] accumulation ACE2 angiotensin angiotensin-converting enzyme 2 Anti-viral appearance BAL baseline Bronchoalveolar lavage CD163 CD68 Cell cell suspension changes in clearance of SARS-CoV-2 correlated COVID-19 patients COVID-19-related death dendritic cells emergence exhibiting expressing expression gene signature heterogeneous HLADR host response host responses Human immune Immune cell immune profiling immunopathology increased risk individual cells infected with SARS-CoV-2 Infection Inflammation Inflammatory Innate immunity interferon interferon response lung Lungs macaque macaques Macrophage macrophages Mutant SARS-CoV-2 myeloid observé plasmacytoid dendritic cell plasmacytoid dendritic cells Population reported response rhesus macaque rhesus macaques RNAseq SARS-CoV-2 SARS-COV-2 infection scRNAseq SIGLEC1 significantly Single Cell strain T-lymphocyte T-lymphocytes transcriptional transcriptional change Transcriptional changes Type type I interferon type I interferon response Viral viral clearance viral dynamics viral infection Viremia while [DOI] 10.1038/s41467-022-28315-7 PMC 바로가기 [Article Type] Article
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells인간 윤부 줄기세포에서 SARS-CoV2 바이러스 진입 관련 단백질의 고발현Article Published on 2022-01-012022-09-11 Journal: The Ocular Surface [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] ABCB5 ACE2 ACE2 expression ACE2 mRNA acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed caused Cell cell population cellular cellular tropism conjunctival coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 testing Culture datasets deficiency Donor epithelial cell epithelial cells evaluated Express expression expression value flow cytometry gene knockout immunohistochemistry knockdown Limbal stem cells mechanism ocular Ocular surface overexpression Patient PAX6 promote Protein Proteins qRT-PCR regulate Regulation RNA-Seq RNAseq SARS-CoV2 SARS-CoV2 infection severe acute respiratory syndrome Coronavirus siRNA stem cell stem cells susceptibility TMPRSS2 TMPRSS2 expression TMPRSS2. transcription factor Transmission routes transplantation viral entry was performed were assessed western blot while [DOI] 10.1016/j.jtos.2021.10.002 PMC 바로가기 [Article Type] Article
Detection of A-to-I RNA Editing in SARS-COV-2SARS-COV-2에서 A-to-I RNA 편집 검출Article Published on 2021-12-232022-09-10 Journal: Genes [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] ADAR change clinical samples Course COVID-19 patient COVID-19 patients Deamination detection double-stranded RNA events exonic regions experiment Genome human cell line identify innate immune response majority metatranscriptomic modulating nonsynonymous RNA RNA editing RNAseq RNAseq data SARS-CoV-2 SARS-CoV-2 genomes target therapeutic interventions Transcriptome Vero Cell Vero cells Viral viral genome virus–host interaction while [DOI] 10.3390/genes13010041 PMC 바로가기 [Article Type] Article
Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii전체 게놈 시퀀싱 및 전 사체의 통합은 주요 말라리아 벡터 Anopheles coluzzii에서 살충제 저항성의 재건에 대한 복잡한 그림을 보여줍니다.Research Article Published on 2021-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alteration Anophele approach block change changes in colony complex complexity determine diagnostic Diagnostic markers elevated expression of gene Genetic genetic background Genome genomic genomic change increase in increased respiratory rate increasingly insecticide integration inversion Laboratory malaria malaria control malaria vector marker mechanism metabolism microbial Microbiome original oxidative phosphorylation pathway phenotype Population Pyrethroids respiratory rate reveal RNAseq Sequencing subject subset susceptible Transcriptome transcriptomic transcriptomics translated whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1009970 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome with inclusion of pathobiontsSARS-COV-2 감염Comparative Study Published on 2021-12-152022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] analysis archaeal bacterial species bacterial specy collected Computational biology and bioinformatics COVID-19 COVID-19 patients determined by diagnostics Diseases Effect feature fraction functional gene genetics genomic healthy healthy control healthy controls host immunity in viral Inclusion information Interaction mapped metabolic functions metabolic pathway metabolic pathways metagenomic Microbiology Microbiome microbiota Molecular biology nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples pandemic disease pathophysiology progression reduce respiratory RNAseq SARS-CoV-2 SARS-COV-2 infection Therapeutics Viral [DOI] 10.1038/s41598-021-03245-4 PMC 바로가기 [Article Type] Comparative Study